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Domenico Coppola, MD

Pathologist

Personal Information

Domenico Coppola, MD, is the medical director of Florida Digestive Health Specialists’ Department of Pathology and Emeritus Professor of Oncologic Sciences and Pathology at Moffitt Cancer Center. He is board-certified in Anatomic and Clinical Pathology. Dr. Coppola completed his fellowship in Surgical Pathology at the University of Pittsburgh Medical Center. He also completed a fellowship in Molecular Biology at Jefferson Cancer Institute.  Dr. Coppola completed his residency in combined anatomic and clinical pathology at Temple University, Philadelphia.

Honors and Awards

  • Center Director’s Award for Outstanding Research,
  • H. Lee Moffitt Cancer Center & Research Institute,Tampa, FL, 1998
  • Research and Creative Scholarship Award. H. Lee Moffitt Cancer Center and Research Institute. IGF1-ROver expression Induces transformation of normal ovarianmesothelial cells, 1998
  • ASCO MeritAward, Senior Author- American Society ofClinical Oncology, An immunohistochemicalanalysis of 72 cases, Strong Correlation between COX-2 expression and AC mutation in left vs. right-sided human colon cancer, 2003
  • Moffitt Leadership Academy, 2006-2007
  • Murray “Gus” Abell, MD, Scientific Paper Award – Human Pathology published article “Activations of the Serine/Threonine Kinase Akt in the Progression of Barrett Neoplasia,” 2007
  • Moffitt’s Team Publication Award, Article in the Journal of the National Cancer Institute, Prognostic and PredictiveValue of a Malignancy-Risk Gene Signature in Early-Stage Non-Small Cell Lung Cancer. February 2012
  • 2012 JOGS Best Article Award for published article“Complementary strand microRNA’s mediate acquisition of metastatic potential in colonic adenocarcinoma” which was published in The Journal of Gastrointestinal Surgery January 2012.
  • The Best Clinical Podium Presentation Award was presented at the 2013 ASCRS Annual Meeting for the article “Epigenomic Characterization of Locally Advanced Stage Anal Cancer: An RTOG 98-11 Specimen Study.”
  • Expression of Her-2 neu in gastroesophageal Intestinal Metaplasia, Dysphasia and adenocarcinoma. Best Research Poster – ASCP meeting in Tampa, FL, October 8- 11, 2014
  • Forecasting H. Pylori-associated gastric disease progression to improve screening modalities for early gastric cancer intervention. IMO Moffitt Cancer Center Workshop IV. Viruses in Cancer. November 21, 2014. Tampa, FL

Publications

  • Saller J, Al Diffalha S, Neill K, Bhaskar RA, Oliveri C, Boulware D, Levine H, Kalvaria I, Corbett FS, Khazanchi A, Klapman J, Coppola D. CDX-2 Expression in Esophageal Biopsies Without Goblet Cell Intestinal Metaplasia May Be Predictive of Barrett’s Esophagus. Dig Dis Sci. 2019 Nov 5. doi: 10.1007/s10620-019-05914-x.  [Epub ahead of print] PMID: 31691172
  • Dandawate P, Kaushik G, Ghosh C, Standing D, Sayed AAA, Choudhury S, Subramaniam D, Manzardo A, Banerjee T, Santra S, Ramamoorthy P, Butler M, Padhye SB, Baranda J, Kasi A, Sun W, Tawfik O, Coppola D, Malafa M, Umar S, Soares MJ, Saha S, Weir SJ, Dhar A, Jensen RA, Thomas SM, Anant S. Diphenylbutylpiperidine Antipsychotic Drugs Inhibit Prolactin Receptor Signaling to Reduce Growth of Pancreatic Ductal Adenocarcinoma in Mice. Gastroenterology. 2019 Nov 28. pii: S0016-5085(19)41867-2. doi: 10.1053/j.gastro.2019.11.279. [Epub ahead of print] PMID: 31786131
  • Walker R, Poleszczuk J, Mejia J, Lee JK, Pimiento JM, Malafa M, Giuliano AR, Enderling H, Coppola D. Toward Early Detection of Helicobacter Pylori-Associated Gastric Cancer.  Gastric Cancer. 2017 Jul 19. Doi: 10.1007/s10120-017-0748-z. (Epub ahead of print).  PMID:  28725964.
  • Rho JH, Ladd JJ, Li CI, Potter JD, Zhang Y, Shelley D, Shibata D, Coppola  Yamada H, Toyoda H, Tada T, Kumada T, Brenner DE, Hanash SM, Lampe PD.  Protein and glycomic plasma markers for early detection of adenoma and colon cancer.  Gut. 2016 Nov 7. pii:gutjnl-2016-312794. doi: 10.1136/gutjnl-2016-312794.  PMID:27821646.
  • Baffa C, Naaman A, Coppola D. Sebaceous Gland Ectopia of the Esophagus: A Challenging Clinical Diagnosis. In Vivo. 2022 Nov-Dec;36(6):2923-2926. doi: 10.21873/invivo.13034. PMID: 36309366; PMCID: PMC9677798.
  • Bora-Singhal N, Saha B, Mohankumar D, Padmanabhan J, Coppola D, Chellappan S. A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis. Cancer Res Commun. 2022 Jul;2(7):624-638. doi: 10.1158/2767-9764.crc-21-0084. Epub 2022 Jul 12. PMID: 35937460; PMCID: PMC9351435.
  • Saller JJ, Mora LB, Nasir A, Mayer Z, Shahid M, Coppola D. Expression of DNA Mismatch Repair Proteins, PD1 and PDL1 in Barrett’s Neoplasia. Cancer Genomics Proteomics. 2022 Mar-Apr;19(2):145-150. doi: 10.21873/cgp.20310. PMID: 35181584; PMCID: PMC8865038.
  • Saller JJ, Haider M, Al-Diffalha S, Coppola D. Benefit of Gene Expression Profiling in Gastrointestinal Neuroendocrine Tumors of Unknown Primary Origin. Anticancer Res. 2022 Mar;42(3):1381-1396. doi: 10.21873/anticanres.15608. PMID: 35220231.
  • Eakins RA, Chobrutskiy A, Teer JK, Patel DN, Hsiang M, Huda TI, Zaman S, Sexton WJ, Coppola D, Falasiri S, Blanck G, Chobrutskiy BI. Chemical complementarity between tumor resident, T-cell receptor CDR3s and MAGEA3/6 correlates with increased melanoma survival: Potential relevance to MAGE vaccine auto-reactivity. Mol Immunol. 2022 Oct;150:58-66. doi: 10.1016/j.molimm.2022.08.001. Epub 2022 Aug 17. PMID: 35987136.
  • Ganapathy K, Ngo C, Andl T, Coppola D, Park J, Chakrabarti R. Anticancer function of microRNA-30e is mediated by negative regulation of HELLPAR, a noncoding macroRNA, and genes involved in ubiquitination and cell cycle progression in prostate cancer. Mol Oncol. 2022 Aug;16(16):2936-2958. doi: 10.1002/1878-0261.13255. Epub 2022 Jun 14. PMID: 35612714; PMCID: PMC9394257.
  • Nasir A, Hough B, Baffa C, Khazanchi A, Coppola D. An Analysis of the Impact of COVID-19 Pandemic-related Lockdown Measures on a Large Gastrointestinal Pathology Service in the United States. Cancer Diagn Progn. 2022 Jul 3;2(4):422-428. doi: 10.21873/cdp.10125. PMID: 35813009; PMCID: PMC9254096.
  • Mora LB, Hough M, Moscinski L, Gomez J, Coppola D. Incidental Gastric Langerhans Cell Histiocytosis and Synchronous Adenocarcinoma of the Colon: An Interesting Case Report and Literature Review. Cancer Diagn Progn. 2023 Jan 3;3(1):102-106. doi: 10.21873/cdp.10186. PMID: 36632587; PMCID: PMC9801445.
  • Saller J, White D, Hough B, Yoder S, Whiting J, Chen DT, Magliocco A, and Coppola D. An miRNA Signature Predicts Grading of Pancreatic Neuroendocrine Neoplasms. Cancer Genomics Proteomics. 2023 (in print).

Patents

  • Coppola D. MiRNA as markers of progression in Barrett’s esophagus. Serial No: 15/171,713
  • Mulé J,Coppola D, Yeatman T, Laboda A, Nebozhyn M. Gene signatures of lymph node formation in colorectal cancer. Serial No. 61/299,798

Certifications

  • Certified American Board of Pathology, combined Anatomic and Clinical Pathology
  • Licenses in the states of Florida, Pennsylvania and Indiana

Degrees/Qualifications

  • Fellow, Surgical Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA. (Under the supervision of Samuel Yousem), 1994-1995
  • Fellow, Molecular Biology, Jefferson Cancer Institute, Thomas Jefferson University Hospital, Philadelphia, PA (under the supervision of Prof. Renato Baserga), 1992-1994
  • Resident, Combined Anatomic and Clinical Pathology, Temple University Hospital, Philadelphia, PA, 1988-1992
  • Resident, General Surgery, Monmouth Medical Center, Long Branch, 1987-1988
  • Post-Doctoral, Associate of the Italian Diabetic Center, Cava dei Tirreni, Italy, 1984-1986
  • Post-doctoral, Gastroenterology, Instituto di Semeiotica Medica, University of Naples, Naples, Italy, 1983-1984
  • MD, University of Naples, First Faculty, Naples, Italy, 1983
  • Internship, University of Naples, Naples, Italy
  • Bachelor of Science/Biology, Liceo Classico P. Virgilio Marone, Meta di Sorrento, Italy, 1974