Physicians: Xiaoping Zhou MD, PhD, Pathologist

Xiaoping Zhou, MD, PhD, FCAP

Personal Information

Dr. Xiaoping Zhou is a board-certified AP&CP pathologist, who provides clinical diagnostic services for Florida Digestive Health Specialists. He joined us from Rhode Island, where he served the largest hospital in the State. Dr. Zhou enjoys spending quality time with his family, hiking, kayaking, fishing and exploring National and State Parks.


    • American Board of Pathology, combined Anatomic and Clinical Pathology
    • License in the states of Florida, Rhode Island and Ohio

    Degrees and Qualifications

    • The Ohio State University Wexner Medical Center, Columbus, OH: Clinical Fellowship, Gastrointestinal and Liver Pathology
    • The Ohio State University Wexner Medical Center, Columbus, OH: Residency, Anatomic and Clinical Pathology
    • Changzheng Hospital, Second Military Medical University, Shanghai, China: Residency, Neurosurgery
    • Second Military Medical University, Shanghai, China: PhD, Immunology
    • Second Military Medical University, Shanghai, China: Bachelor of Medicine

    Honors and Awards

    • 2011 - Best Abstract Award, International Association of Chinese Pathologists, USCAP Annual Meeting 2011, San Antonio
    • 2009 - Travel Award, GI Pathology Society, USCAP Annual Meeting 2009, Boston
    • 2001 - First Place Prize (Trainee session), the American Association of Chinese Geneticists, American Society of Human Genetics Annual Meeting 2001, San Diego
    • 1996-1998 - Research Fellowship Award, Assistance Publique-Hopitaux de Paris, CRC 95277, French Association for Brain Tumor Research. “Molecular pathology of malignant brain tumors”

    Professional Memberships

    • American Society for Clinical Pathology
    • United States and Canadian Academy of Pathology
    • College of American Pathologists
    • Ohio Society of Pathologists
    • Rhode Island Society of Pathologists

    Selected Publications

    • Jin M, Zhou X, Yearsley M, Frankel W. Liver metastases of neuroendocrine tumors rarely show overlapping immunoprofile with hepatocellular carcinomas. Endoc Pathol. 2016 Sep; 27(3):253-8.
    • Chen W, Frankel WL, Cronley KM, Yu L, Zhou X, Yearsley MM. Significance of Paneth cell metaplasia in Barrett esophagus: a morphologic and clinicopathologic study. Am J Clin Pathol. 2015 May;143(5):665-71.
    • Jin M, Hampel H, Zhou X, Schunemann L, Yearsley M, Frankel WL. BRAF V600E mutation analysis simplifies the testing algorithm for Lynch syndrome. Am J Clin Pathol. 2013 Aug;140(2):177-83.
    • Gerber MM, Hampel H, Zhou X, de la Chapelle A, Toland AE. Evaluation of Allele-Specific Somatic Changes of Genome-Wide Association Study Susceptibility Alleles in Human Colorectal Cancers. PLoS One. 2012;7(5):e37672. Epub 2012 May 21.
    • Bellizzi AM, Bloomston M, Zhou X, Iwenofu OH, Frankel WL. The mTOR pathway is frequently activated in pancreatic ductal adenocarcinoma and chronic pancreatitis. Appl Immunohistochem Mol Morphol. 2010 Oct;18(5):442-7.
    • Spearman A, Sweet K, Zhou X, McClennan J, Couch FJ, Toland AE. Clinical applicable models for the characterization of BRCA1 and BRCA2 variants of uncertain significance. J Clin Oncol, 2008 Nov; 20;26(33):5393-400.
    • Abdel-Rahman MH, Yang Y, Zhou X, Craig EL, Davidorf FH, Eng C. High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma. J Clin Oncol. 2006 Jan 10;24(2):288-95.
    • Sweet K, Willis J, Zhou, X, Gallione C, Sawada T, Alhopuro P, Khoo SK, Patocs A, Martin C, Bridgeman S, Heinz J, Pilarski R, Lehtonen R, Prior TW, Frebourg T, Teh BT, Marchuk DA, Aaltonen LA, Eng C. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. JAMA. 2005 Nov 16;294(19):2465-73.
    • Zhou X, Marsh DJ, Morrison CD, Chaudhury AR, Maxwell M, Reifenberger G and Eng C Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase/Akt pathway cause human Lhermitte-Duclos disease in adults. Am J Hum Genet 2003 Nov; 73(5):1191-1198.
    • Zhou X, Loukola A, Salovaara R, Nystrom-Lahti M, Peltomäki P, de la Chapelle A, Aaltonen LA, Eng C. PTEN mutational spectra, expression levels and subcellular localization in microsatellite stable and unstable colorectal cancers. Am J Pathol 2002; 161(2): 439-47.
    • Zhou X, Hampel H, Roggenbuck J, Saba N, Prior TW, Eng C. A 39-bp deletion polymorphism in PTEN in african-american individuals: implications for molecular diagnostic testing. J Mol Diagn 2002; 4(2):114-7.
    • Zhou X, Kuismanen S, Nyström-Lahti M, Peltomäki P, Eng C. Distinct PTEN mutational spectra in endometrial carcinomas from hereditary non-polyposis colon cancer syndrome cases compared to sporadic microsatellite unstable tumors. Hum Mol Genet 2002; 11(4):445-50.
    • Zhou X, Hampel H, Lentze M, Hennekam RC, Winter RC, Parisi M, Eng C. Association of germline mutation in the PTEN tumor suppressor gene and Proteus and Proteus-like syndromes. Lancet 2001 Jul 21; 358:210-11.
    • Zhou X, Gimm O, Hampel H, Niemann T, Walker MJ, Eng C. Epigenetic PTEN silencing in malignant melanomas without PTEN mutation. Am J Pathol 2000; 157(4):1123-8.
    • Zhou X, Marsh DJ, Hampel H, Mulliken JB, Gimm O, Eng C. Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. Hum Mol Genet 2000; 9(5):765-8.
    • Zhou X, Sanson M, Hoang-Xuan K, Robin E, Taillandier L, He J, Mokhtari K, Cornu P, Delattre JY, Thomas G, Hamelin R and the French Group of the ANOCEF. Germline mutations of p53, but not p16/CDKN2 and PTEN/MMAC1 tumor suppressor genes, predispose to gliomas. Ann Neurol 1999; 46(6):913-6.
    • Zhou X, Hoang JM, Li YJ, Seruca R, Carneiro F, Sobrinho-Simoes M, Lothe RA, Gleeson CM, Ruessell SEH, Muzeau F, Fléjou JF, Hoang-Xuan K, Lidereau R, Thomas G and Hamelin R. Determination of the replication error phenotype of human tumors without the need of matching normal DNA by analysis of mononucleotide repeat microsatellites. Genes Chromosomes Cancer 1998; 21(2):101.